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Baltimore is an independent city and the largest city and cultural center of the U.S. state of Maryland. The city is located in central Maryland along the tidal portion of the Patapsco River, an arm of the Chesapeake Bay. Baltimore is sometimes referred to as Baltimore City in order to distinguish it from surrounding Baltimore County. Founded in 1729, Baltimore is a major U.S. seaport and is situated closer to major Midwestern markets than any other major seaport on the East Coast. Baltimore’s Inner Harbor was once the second leading port of entry for immigrants to the United States and a major manufacturing center. The harbor is now home to the Harborplace, a shopping, entertainment, and tourist center, and the National Aquarium in Baltimore. After a decline in manufacturing industries, Baltimore shifted to a service sector-oriented economy. Johns Hopkins University and Johns Hopkins Hospital are now the city’s largest employers.